alienzj | Microbiome InformaticsResearcher & Bioinformatics Engineer focused on metagenomics, MAGs, and AI for Science. Open-source contributor @ohmeta, @metagenome-atlas, @bioconda.https://alienzj.org/IDBA-UD 组装器深度解析：从多级迭代到局部组装https://alienzj.org/blog/idba-ud-assembler/https://alienzj.org/blog/idba-ud-assembler/系统讲解 IDBA-UD 算法如何通过多 k 迭代和局部组装技术，攻克单细胞测序和宏基因组中覆盖度极度不均一的组装难题Thu, 19 Mar 2026 00:00:00 GMT微生物组 R 包全景指南：从 phyloseq 到 SIAMCAThttps://alienzj.org/blog/microbiome-r-package-guide/https://alienzj.org/blog/microbiome-r-package-guide/系统梳理微生物组分析的 R 语言生态系统，涵盖数据结构、多样性分析、差异检验、机器学习和网络分析的核心工具包Fri, 20 Mar 2026 00:00:00 GMTBootstrapping NixOS on a 1GB VPS: 5 Bugs, 65% Closure Reduction, and a Working Scripthttps://alienzj.org/blog/nixos-1gb-vps-bootstrap/https://alienzj.org/blog/nixos-1gb-vps-bootstrap/A deep debugging journey: using nixos-anywhere and disko on a 962MB RAM VPS. OOM kills, SIGBUS crashes, SSH failures, persistence bugs, and how we solved each one.Thu, 07 May 2026 00:00:00 GMTVelvet 基因组组装器详解：从论文到 C 代码实现https://alienzj.org/blog/velvet-genome-assembler/https://alienzj.org/blog/velvet-genome-assembler/系统讲解 Velvet 基因组组装算法的原理、设计和实现，包括 de Bruijn 图构建、错误校正和图简化等核心模块Fri, 13 Mar 2026 00:00:00 GMTWhy Does diamond blastp Stall on HDD? A Deep Dive into Random I/Ohttps://alienzj.org/blog/why-diamond-blastp-stalls-on-hdd/https://alienzj.org/blog/why-diamond-blastp-stalls-on-hdd/Exploring the performance bottleneck of random I/O on mechanical hard drives when running diamond blastp, with benchmarks and technical analysis.Mon, 23 Mar 2026 00:00:00 GMT